Lecture 7
- Regulation through modifying histone tails
- Targets specific amino acids
- Lysine, Arginine, Serine (less common)
- Three methods
- Methylation
- Acetylation
- Phosphorylation
- Histone tail modification
- Variant effects depending on method/amino acid
- Examples
- Acetylation of Lysine removes the polarity
- Results in weaker nucleosome bonds and more sliding
- Trimethylation on a H3 Lysine -> more heterochromatin
- Acetylation of Lysine removes the polarity
- Reader complex
- Histone tails attract reader complexes that recruit other proteins
- Targets specific amino acids